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MSGR - Harold M. Swartz M.D., PhD

Thursday, December 17, 2015 07:30am - 08:30pm

Harold M. Swartz M.D., PhD

Geisel School of Medicine at Dartmouth

"A new clinical tool to enhance therapy for diseases involving alterations in tissue oxygen: Clinical results and plans for future applications."

Abstract: Many pathophysiological processes are very significantly affected by the amount of oxygen in the tissues (best described as the partial pressure of oxygen, pO2). These include cancer, peripheral vascular disease, wound healing, and ischemia-reperfusion injury. While this is widely appreciated, previously it has not been feasible to measure tissue pO2 directly and repeatedly under conditions that are applicable for regular clinical practice. Recent developments in Electron Paramagnetic Resonance (EPR) in vivo oximetry have overcome this barrier. Using this technique, clinical studies have been initiated at Dartmouth and collaborating institutions with very encouraging initial results. The presentation will provide an overview of the capabilities and the results to date in preclinical and clinical studies. It will particularly address ongoing or planned clinical applications in optimizing and individualizing radiation therapy, in optimally combining radiation therapy with surgery and/or chemotherapy, applications to improve wound healing, uses to guide diagnosis and therapeutic interventions in peripheral vascular disease, and determination of susceptibility to chemotherapy induced peripheral neuritis. The aim of the presentation is both to describe this exciting and productive new clinical capability and to facilitate possible collaborations with the clinical programs at McGill.

Location : MGH - Osler A6-105, RVH/Glen - B06.3626, JGH - B.105, St.Mary-1501E,Lachine-0J5,Barrie-room 3